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Ligand · CQE

CQE · N-{4-[2-(1-cyclopropylpiperidin-4-yl)-4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-5-yl]pyridin-2-yl}acetamide

CQE, N-{4-[2-(1-cyclopropylpiperidin-4-yl)-4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-5-yl]pyridin-2-yl}acetamide (C30 H28 F3 N5 O3 S2, 627.7 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1…

Component
CQE
Formula
C30 H28 F3 N5 O3 S2
Class
ligand
Structures
2
PDB entries
1

Binding sites

CQE in 2 structures; the first of them:

  • 4CQE · B-Raf Kinase V600E mutant in complex with a diarylthiazole B-Raf Inhibitor · CQE A1721 · binds ILE463, SER465, VAL471, ALA481, LYS483, LEU505, LEU514, LEU515 and 16 more
  • 4CQE · B-RAF kinase V600E mutant in complex with a diarylthiazole B-RAF inhibitor · CQE A1721 · binds ILE463, SER465, VAL471, ALA481, LYS483, LEU505, LEU514, LEU515 and 16 more

Residues it binds most

ILE 4, LEU 4, PHE 4, GLY 4, ASN 4, VAL 4, ALA 4, ASP 4, CYS 4, GLN 4 (residue and the binding sites it lines).

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