BCZ · 3-(1-acetylamino-2-ethyl-butyl)-4-guanidino-2-hydroxy-cyclopentanecarboxylic acid

Binding sites

BCZ in 8 structures; the first of them:

• 1L7F · Crystal structure of influenza virus neuraminidase in complex with BCX-1812 · BCZ A801 · binds ARG118, GLU119, LEU134, ASP151, ARG152, ARG156, TRP178, SER179 and 10 more
• 1L7G · Crystal structure of E119G mutant influenza virus neuraminidase in complex with BCX-1812 · BCZ A801 · binds ARG118, LEU134, ASP151, ARG152, ARG156, TRP178, SER179, ILE222 and 10 more
• 1L7H · Crystal structure of R292K mutant influenza virus neuraminidase in complex with BCX-1812 · BCZ A801 · binds ARG118, GLU119, LEU134, ASP151, ARG152, ARG156, TRP178, SER179 and 9 more
• 2F10 · Crystal Structure of the Human Sialidase Neu2 in Complex with Peramivir inhibitor · BCZ A382 · binds ARG21, ILE22, GLU39, ARG41, MET85, ASN86, TYR179, TYR181 and 6 more
• 2HTU · N8 neuraminidase in complex with peramivir · BCZ A801 · binds ARG118, GLU119, LEU134, ASP151, ARG152, ARG156, TRP180, SER181 and 10 more
• 7FGE · A naturally-occurring neuraminidase-inhibitors-resistant NA from asiatic toad influenza… · BCZ A501 · binds ARG116, LEU132, ASP148, ARG149, ARG153, TRP176, SER177, ILE220 and 9 more
• 7XVW · Structure of neuraminidase from influenza B-like viruses derived from spiny eel · BCZ A501 · binds ARG121, GLU122, LEU137, ASP154, ARG155, ARG159, TRP182, SER183 and 10 more
• 7FGE · A naturally-occurring neuraminidase-inhibitors-resistant na from asiatic toad influenza… · BCZ A501 · binds ARG116, LEU132, ASP148, ARG149, ARG153, TRP176, SER177, ARG222 and 7 more

Residues it binds most

ARG 23, GLU 23, ASP 22, TYR 23, TRP 22, LEU 21, SER 17, ASN 16, ILE 15, ALA 5 (residue and the binding sites it lines).

Found with

• CA · Calcium ion
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
• BMA · beta-D-mannopyranose
• MAN · alpha-D-mannopyranose
• GOL · Glycerol
• PO4 · Phosphate ion