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Ligand · 8W4

8W4 · N-{(1S,2S)-1-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-1-hydroxy-3-phenylpropan-2-yl}-7-ethyl-1,3,3-trimethyl-2,2-dioxo-1,2,3,4-tetrahydro-2lambda~6~-[1,2, 5]thiadiazepino[3,4,5-hi]indole-9-carboxamide

8W4, N-{(1S,2S)-1-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-1-hydroxy-3-phenylpropan-2-yl}-7-ethyl-1,3,3-trimethyl-2,2-dioxo-1,2,3,4-tetrahydro-2lambda~6~-[1,2, 5]thiadiazepino[3,4,5-hi]indole-9-carboxamide (C36 H43 N5 O5 S, 657.8 g/mol), in the…

Component
8W4
Formula
C36 H43 N5 O5 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

8W4 in 2 structures; the first of them:

  • 5V0N · BACE1 in complex with inhibitor 5g · 8W4 A404 · binds GLY11, GLN12, GLY13, LEU30, ASP32, GLY34, SER35, VAL69 and 19 more
  • 5V0N · BACE1 in complex with inhibitor 5G · 8W4 A404 · binds GLY11, GLN12, GLY13, LEU30, ASP32, GLY34, SER35, VAL69 and 19 more

Residues it binds most

GLY 6, ILE 6, THR 6, ASP 6, GLN 6, SER 6, TYR 6, PRO 6, ARG 6, ASN 6 (residue and the binding sites it lines).

Found with

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