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Ligand · 8G3

8G3 · 2-methyl-5-[2-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl) ethyl]pyrazolo[1,5-a]pyrimidin-7-ol

8G3, 2-methyl-5-[2-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl) ethyl]pyrazolo[1,5-a]pyrimidin-7-ol (C14 H13 N7 O, 295.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within…

Component
8G3
Formula
C14 H13 N7 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

8G3 in 2 structures; the first of them:

  • 5XUI · Crystal structure of PDE10A in complex with 2-methyl-5-[2-([1,2,4]triazolo[1,5-a]pyrimidin… · 8G3 A803 · binds LEU675, SER677, VAL678, ILE692, TYR693, PHE696, PRO712, MET713 and 5 more
  • 5XUI · Crystal structure of PDE10A in complex with 2-methyl-5-[2-([1,2… · 8G3 A803 · binds SER677, VAL678, ILE692, TYR693, PHE696, PRO712, MET713, GLY725 and 2 more

Residues it binds most

PHE 2, VAL 2, GLN 2, GLY 2, ILE 2, MET 2, PRO 2, SER 2, TYR 2, GLU 1 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • ZN · Zinc ion

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