GL1X · GenesisL1 explorer

Ligand · 7ZR

7ZR · 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

7ZR, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide (C17 H15 N3 O6 S2, 421.4 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the…

Component
7ZR
Formula
C17 H15 N3 O6 S2
Class
ligand
Structures
6
PDB entries
3

Binding sites

7ZR in 6 structures; the first of them:

  • 5X6Q · Crystal structure of Pseudomonas fluorescens KMO in complex with Ro 61-8048 · 7ZR A502 · binds ALA56, ARG84, GLN96, LEU213, ILE224, LEU226, PHE238, PRO318 and 6 more
  • 5X6R · Crystal structure of Saccharomyces cerevisiae KMO in complex with Ro 61-8048 · 7ZR A402 · binds ASN51, ALA53, ARG83, TYR97, ILE104, LEU221, ILE223, ILE232 and 11 more
  • 5Y66 · Crystal structure of Pseudomonas fluorescens Kynurenine 3-monooxygenase in complex with… · 7ZR A502 · binds ARG84, GLN96, GLU368, GLU372, TYR382, GLU385, ARG386, GLY389 and 10 more
  • 5X6Q · Crystal structure of pseudomonas fluorescens kmo in complex with ro 61-8048 · 7ZR A502 · binds ALA56, ARG84, GLN96, LEU213, ILE224, LEU226, PHE238, PRO318 and 6 more
  • 5X6R · Crystal structure of saccharomyces cerevisiae kmo in complex with ro 61-8048 · 7ZR A402 · binds ASN51, ALA53, ARG83, LEU221, ILE223, ILE232, LEU234, THR242 and 8 more
  • 5Y66 · Crystal structure of pseudomonas fluorescens kynurenine 3- monooxygenase in complex with… · 7ZR A502 · binds ARG84, GLN96, GLU372, TYR382, GLU385, ARG386, GLY389, GLN390 and 8 more

Residues it binds most

ARG 10, GLN 10, LEU 10, PHE 10, TYR 10, GLU 4, GLY 9, ILE 7, THR 6, PRO 9 (residue and the binding sites it lines).

Found with

  • FAD · Flavin-adenine dinucleotide
  • KYN · (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid

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