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Ligand · 7NZ

7NZ · 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2S,4S,7aR)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)naphthalen-2-ol

7NZ, 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2S,4S,7aR)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)naphthalen-2-ol (C31 H32 F2 N6 O2, 558.6 g/mol), in the MolNFT structures on…

Component
7NZ
Formula
C31 H32 F2 N6 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

7NZ in 2 structures; the first of them:

  • 7RT3 · Crystal Structure of KRAS G12D with compound 24… · 7NZ A202 · binds GLY10, ALA11, ASP12, ALA59, GLY60, GLN61, GLU62, GLU63 and 13 more
  • 7RT3 · Crystal structure of KRAS G12D with compound 24 (4-(4-[(1R,5S)-3,8… · 7NZ A202 · binds GLY10, ALA11, ASP12, ALA59, GLY60, GLN61, GLU62, GLU63 and 13 more

Residues it binds most

ASP 2, ALA 2, ARG 2, GLN 2, GLU 2, GLY 2, TYR 2, HIS 2, ILE 2, LYS 2 (residue and the binding sites it lines).

Found with

  • GDP · Guanosine-5'-diphosphate
  • MG · Magnesium ion

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