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Ligand · 7MG

7MG · 7N-methyl-8-hydroguanosine-5'-monophosphate

7MG, 7N-methyl-8-hydroguanosine-5'-monophosphate (C11 H18 N5 O8 P, 379.3 g/mol), in the MolNFT structures on GenesisL1: bound in 9 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and…

Component
7MG
Formula
C11 H18 N5 O8 P
Class
ligand
Structures
9
PDB entries
5

Binding sites

7MG in 9 structures; the first of them:

  • 1H2T · Structure of the human nuclear cap-binding-complex (CBC) in complex with a cap analogue… · 7MG Z1152 · binds TYR20, ASP22, TYR43, PHE83, PHE85, ARG112, ASP114, TRP115 and 9 more
  • 1H2U · Structure of the human nuclear cap-binding-complex (CBC) in complex with a cap analogue… · 7MG X1154 · binds TYR20, ASP22, TYR43, PHE83, PHE85, ARG112, ASP114, TRP115 and 10 more
  • 2ROK · Solution structure of the cap-binding domain of PARN complexed with the cap analog · 7MG A523 · binds PHE445, LYS447, TRP449, LYS450, THR451, TRP468, ASP470, ASP471
  • 3D45 · Crystal structure of mouse PARN in complex with m7GpppG · 7MG A651 · binds LYS319, ASN332, ASN333, SER335, MET418, PHE445, LYS447, TRP449 and 5 more
  • 9F3F · Trypanosoma brucei nuclear cap-binding complex (CBC) bound to cap0 · 7MG 2201 · binds MET12, TYR14, ASP16, TYR45, PHE85, PHE87, SER116, TRP117 and 4 more
  • 1H2T · Structure of the human nuclear cap-binding-complex (cbc) in complex with a cap analogue… · 7MG Z1152 · binds TYR20, ASP22, TYR43, PHE83, PHE85, ARG112, ASP114, TRP115 and 9 more
  • 1H2U · Structure of the human nuclear cap-binding-complex (cbc) in complex with a cap analogue… · 7MG X1154 · binds TYR20, ASP22, TYR43, PHE83, PHE85, ARG112, ASP114, TRP115 and 10 more
  • 2ROK · Solution structure of the cap-binding domain of parn complexed with the cap analog · 7MG A523 · binds PHE445, LYS447, TRP449, LYS450, THR451, TRP468, ASP470, ASP471
  • 3D45 · Crystal structure of mouse parn in complex with M7GPPPG · 7MG B1152 · binds THR41, PHE445, LYS447, TRP449, LYS450, THR451, TRP468, ASP470 and 2 more

Residues it binds most

ASP 12, ARG 7, TYR 7, GLY 7, PHE 12, TRP 12, LYS 5, THR 5, GLN 6, VAL 6 (residue and the binding sites it lines).

Found with

  • GDP · Guanosine-5'-diphosphate

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