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Ligand · 615

615 · (1R,2S)-N~2~-hydroxy-1-{4-[(2-phenylquinolin-4-yl)methoxy]benzyl}cyclopropane-1,2-dicarboxamide

615, (1R,2S)-N~2~-hydroxy-1-{4-[(2-phenylquinolin-4-yl)methoxy]benzyl}cyclopropane-1,2-dicarboxamide (C28 H25 N3 O4, 467.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
615
Formula
C28 H25 N3 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

615 in 2 structures; the first of them:

  • 3E8R · Crystal structure of catalytic domain of TACE with hydroxamate inhibitor · 615 A486 · binds GLY346, THR347, LEU348, GLY349, LEU350, GLU398, LEU401, VAL402 and 12 more
  • 3E8R · Crystal structure of catalytic domain of tace with hydroxamate inhibitor · 615 A486 · binds GLY346, THR347, LEU348, GLY349, LEU350, GLU398, LEU401, VAL402 and 12 more

Residues it binds most

HIS 4, LEU 4, GLY 4, VAL 4, GLU 4, TYR 4, ALA 4, ASN 4, ILE 4, LYS 4 (residue and the binding sites it lines).

Found with

  • INN · N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide
  • ZN · Zinc ion
  • CIT · Citric acid

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