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Ligand · 4HF

4HF · N-[(5-{2-[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}-2-thienyl)carbonyl]-L-glutamic acid

4HF, N-[(5-{2-[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}-2-thienyl)carbonyl]-L-glutamic acid (C19 H23 N5 O6 S, 449.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
4HF
Formula
C19 H23 N5 O6 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

4HF in 2 structures; the first of them:

  • 2FMN · Ala177Val mutant of E. coli Methylenetetrahydrofolate Reductase complex with LY309887 · 4HF A495 · binds GLU28, PHE30, ARG33, THR59, ASP120, GLN183, PHE184, LEU212 and 7 more
  • 2FMN · ALA177VAL mutant of E. COLI methylenetetrahydrofolate reductase complex with LY309887 · 4HF A495 · binds GLU28, PHE30, ARG33, THR59, ASP120, GLN183, PHE184, LEU212 and 7 more

Residues it binds most

PHE 6, GLN 6, LEU 6, THR 6, ALA 6, ARG 4, ASP 6, GLU 6, TYR 6, MET 2 (residue and the binding sites it lines).

Found with

  • FAD · Flavin-adenine dinucleotide

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