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Ligand · 4FC

4FC · 4'-fluoro-1,1'-biphenyl-4-carboxylic acid

4FC, 4'-fluoro-1,1'-biphenyl-4-carboxylic acid (C13 H9 F O2, 216.2 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
4FC
Formula
C13 H9 F O2
Class
ligand
Structures
4
PDB entries
2

Binding sites

4FC in 4 structures; the first of them:

  • 1YSG · Solution Structure of the Anti-apoptotic Protein Bcl-xL in Complex with "SAR by NMR"… · 4FC A1000 · binds PHE101, TYR105, ALA108, PHE109, LEU112, LEU134, GLY142, ARG143 and 1 more
  • 4N98 · E. coli sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid · 4FC A401 · binds ARG152, TYR154, THR172, GLY174, HIS175, ARG176, LEU177, PRO242 and 5 more
  • 1YSG · Solution structure of the anti-apoptotic protein BCL-xl in complex with "sar by NMR"… · 4FC A1000 · binds PHE101, TYR105, ALA108, PHE109, LEU112, LEU134, GLY142, ARG143 and 1 more
  • 4N98 · E. COLI sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid · 4FC A401 · binds ARG152, TYR154, THR172, GLY174, HIS175, ARG176, LEU177, PRO242 and 5 more

Residues it binds most

ARG 4, LEU 4, VAL 2, ALA 2, GLY 4, PHE 2, TYR 4, HIS 2, MET 2, PRO 2 (residue and the binding sites it lines).

Found with

  • TN1 · 5,6,7,8-tetrahydronaphthalen-1-ol
  • CA · Calcium ion
  • CL · Chloride ion
  • PEG · Di(hydroxyethyl)ether

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