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Ligand · 3FY

3FY · N-(2-{(4-bromophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)-1-methyl-N-(2-methylbenzyl)-1H-imidazole-4-sulfonamide

3FY, N-(2-{(4-bromophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)-1-methyl-N-(2-methylbenzyl)-1H-imidazole-4-sulfonamide (C25 H29 Br N6 O2 S, 557.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
3FY
Formula
C25 H29 Br N6 O2 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

3FY in 2 structures; the first of them:

  • 3SFY · Cryptococcus neoformans protein farnesyltransferase in complex with FPT-II and… · 3FY B525 · binds LYS107, SER108, TYR109, HIS146, LEU84, SER87, TRP90, TRP94 and 6 more
  • 3SFY · Cryptococcus neoformans protein farnesyltransferase in complex with fpt-II and… · 3FY B525 · binds LYS107, SER108, TYR109, HIS146, LEU84, SER87, TRP90, TRP94 and 6 more

Residues it binds most

ASP 2, HIS 2, SER 2, TRP 2, TYR 2, CYS 2, GLN 2, LEU 2, LYS 2 (residue and the binding sites it lines).

Found with

  • 3FX · (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid
  • FII · [(3,7,11-trimethyl-dodeca-2,6,10-trienyloxycarbamoyl)-methyl]-phosphonic acid
  • ZN · Zinc ion
  • SO4 · Sulfate ion

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