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Ligand · 1M7

1M7 · (4R)-2-amino-1,3',3'-trimethyl-7'-(pyrimidin-5-yl)-3',4'-dihydro-2'H-spiro[imidazole-4,1'-naphthalen]-5(1H)-one

1M7, (4R)-2-amino-1,3',3'-trimethyl-7'-(pyrimidin-5-yl)-3',4'-dihydro-2'H-spiro[imidazole-4,1'-naphthalen]-5(1H)-one (C19 H21 N5 O, 335.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
1M7
Formula
C19 H21 N5 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

1M7 in 2 structures; the first of them:

  • 4JPE · Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors · 1M7 A502 · binds GLY59, GLN60, GLY61, LEU78, ASP80, GLY82, SER83, TYR119 and 9 more
  • 4JPE · Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors · 1M7 A502 · binds GLY59, GLN60, GLY61, LEU78, ASP80, GLY82, SER83, TYR119 and 9 more

Residues it binds most

GLY 2, ASP 2, ILE 2, THR 2, TRP 2, GLN 2, LEU 2, PHE 2, SER 2, TYR 2 (residue and the binding sites it lines).

Found with

  • NI · Nickel (II) ion

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