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Ligand · 1M6

1M6 · 3-[(4R)-2'-amino-1',2,2-trimethyl-5'-oxo-1',2,3,5'-tetrahydrospiro[chromene-4,4'-imidazol]-6-yl]benzonitrile

1M6, 3-[(4R)-2'-amino-1',2,2-trimethyl-5'-oxo-1',2,3,5'-tetrahydrospiro[chromene-4,4'-imidazol]-6-yl]benzonitrile (C21 H20 N4 O2, 360.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
1M6
Formula
C21 H20 N4 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

1M6 in 2 structures; the first of them:

  • 4JPC · Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors · 1M6 A502 · binds GLY59, GLN60, GLY61, LEU78, ASP80, GLY82, SER83, VAL117 and 11 more
  • 4JPC · Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors · 1M6 A502 · binds GLY59, GLN60, GLY61, LEU78, ASP80, GLY82, SER83, VAL117 and 11 more

Residues it binds most

GLY 2, ASP 2, ILE 2, SER 2, THR 2, TRP 2, GLN 2, LEU 2, PHE 2, TYR 2 (residue and the binding sites it lines).

Found with

  • NI · Nickel (II) ion

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