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Ligand · 1FY

1FY · (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide

1FY, (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide (C17 H26 N4 O4 S2, 414.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
1FY
Formula
C17 H26 N4 O4 S2
Class
ligand
Structures
2
PDB entries
1

Binding sites

1FY in 2 structures; the first of them:

  • 4ISG · Human glucokinase in complex with novel activator… · 1FY A501 · binds TYR61, VAL62, ARG63, SER64, THR65, PRO66, GLU67, GLN98 and 11 more
  • 4ISG · Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2… · 1FY A501 · binds TYR61, VAL62, ARG63, SER64, THR65, PRO66, GLU67, GLN98 and 11 more

Residues it binds most

MET 2, LYS 2, TYR 2, VAL 2, ARG 2, CYS 2, GLN 2, GLU 2, ILE 2, LEU 2 (residue and the binding sites it lines).

Found with

  • GLC · alpha-D-glucopyranose
  • IOD · Iodide ion

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