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Ligand · 1FW

1FW · (2S)-3-cyclohexyl-2-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-N-(1,3-thiazol-2-yl)propanamide

1FW, (2S)-3-cyclohexyl-2-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-N-(1,3-thiazol-2-yl)propanamide (C20 H21 F N4 O2 S, 400.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues…

Component
1FW
Formula
C20 H21 F N4 O2 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

1FW in 2 structures; the first of them:

  • 4ISE · Human glucokinase in complex with novel activator… · 1FW A501 · binds TYR61, VAL62, ARG63, SER64, THR65, PRO66, GLU67, GLY97 and 12 more
  • 4ISE · Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2… · 1FW A501 · binds TYR61, VAL62, ARG63, SER64, THR65, PRO66, GLU67, GLY97 and 12 more

Residues it binds most

MET 2, LYS 2, TYR 2, VAL 2, ARG 2, CYS 2, GLN 2, GLU 2, GLY 2, ILE 2 (residue and the binding sites it lines).

Found with

  • GLC · alpha-D-glucopyranose
  • IOD · Iodide ion

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