MolNFT v2 · #6729 · protein

Crystal structure of human uropepsin at 2.45 a resolution

1FLH: “Crystal structure of human uropepsin at 2.45 a resolution”. X-ray diffraction at 2.45, 2 pockets (best druggability 0.60). MolNFT v2 #6729 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1FLH
Type: protein
Length: 326 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.45
Source: Homo sapiens
Molecule: Uropepsin
EC: 3.4.23.1
UniProt: P00790
Pockets: 2 · best druggability 0.60

Structure

x-ray diffraction · resolution 2.45 · 1 distinct chain · 16% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uropepsin (EC 3.4.23.1)	protein	326	16% helix, 45% strand	P00790

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	325	0.60	0.77	38	empty
2	59	0.28	0.74	18	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

1FLH · Crystal structure of human uropepsin at 2.45 a resolution · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00790
Elsewhere: RCSB PDB 1FLH · PDBe 1FLH · UniProt P00790

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