MolNFT v2 · #228123 · protein
mouse alpha-synuclein
9EWV: “mouse alpha-synuclein”. Electron microscopy at 2.9, 7 pockets (best druggability 0.76). MolNFT v2 #228123 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 9EWV
- Type
- protein
- Length
- 768 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.9
- Source
- Mus musculus
- Molecule
- Alpha-synuclein
- UniProt
- O55042
- Pockets
- 7 · best druggability 0.76
Structure
electron microscopy · resolution 2.9 · 1 distinct chain · 0% helix, 55% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, I, F, G, H, J, K, L | Alpha-synuclein | protein | 64 | 0% helix, 55% strand | O55042 |
Pockets
7 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 312 | 0.76 | 0.88 | 42 | empty |
| 2 | 312 | 0.75 | 0.87 | 42 | empty |
| 3 | 143 | 0.71 | 0.91 | 24 | empty |
| 4 | 117 | 0.68 | 0.91 | 43 | empty |
| 5 | 112 | 0.66 | 0.90 | 42 | empty |
Interfaces
21 interfaces between chains.
- A–B · 2468 Ų buried · 67 hydrogen bonds · protein-protein
- F–G · 2468 Ų buried · 68 hydrogen bonds · protein-protein
- H–J · 2466 Ų buried · 67 hydrogen bonds · protein-protein
- B–C · 2465 Ų buried · 66 hydrogen bonds · protein-protein
- C–D · 2464 Ų buried · 68 hydrogen bonds · protein-protein
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O55042
- Elsewhere: RCSB PDB 9EWV · PDBe 9EWV · UniProt O55042
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