MolNFT v2 · #226553 · protein
NMR structure of the MLL4 PHD2/3 fingers in complex with ASXL2
9ATN · Histone-lysine N-methyltransferase 2D: “NMR structure of the MLL4 PHD2/3 fingers in complex with ASXL2”. Solution nmr at NOT, 1 ligand (ZN). MolNFT v2 #226553 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 9ATN
- Type
- protein
- Length
- 117 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- NOT
- Source
- Homo sapiens
- Molecule
- Histone-lysine N-methyltransferase 2D; Polycomb group protein ASXL2
- EC
- 2.1.1.364
- UniProt
- O14686, Q76L83
- Ligands
- ZN
Structure
solution nmr · resolution NOT · 2 distinct chains · 23% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-lysine N-methyltransferase 2D (EC 2.1.1.364) | protein | 98 | 12% helix, 10% strand | O14686 |
| B | Polycomb group protein ASXL2 | protein | 19 | 79% helix, 0% strand | Q76L83 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 754 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- Q76L83 · AlphaFold monomer V2.0 prediction for putative polycomb group protein ASXL2 (Q76L83) · a predicted model of the same protein · chain B against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14686
- Every structure of UniProt Q76L83
- Elsewhere: RCSB PDB 9ATN · PDBe 9ATN · UniProt O14686 · UniProt Q76L83
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.