MolNFT v2 · #222531 · protein
The structure of the native cardiac thin filament troponin core in Ca2+-free tilted state from the upper strand
8UWX · Actin, alpha cardiac muscle 1: “The structure of the native cardiac thin filament troponin core in Ca2+-free tilted state from the upper…”. Electron microscopy at 6.0, 14 pockets (best druggability 0.81). MolNFT v2 #222531 on…
- PDB
- 8UWX
- Type
- protein
- Length
- 1,281 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 6.0
- Source
- Sus scrofa
- Molecule
- Actin, alpha cardiac muscle 1; Troponin C, slow skeletal and cardiac muscles; Troponin I…
- UniProt
- B6VNT8, P63317, A0A4X1V710, A0A5G2Q8N0, P42639
- Pockets
- 14 · best druggability 0.81
Structure
electron microscopy · resolution 6.0 · 5 distinct chains · 57% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Actin, alpha cardiac muscle 1 | protein | 375 | 39% helix, 18% strand | B6VNT8 |
| C | Troponin C, slow skeletal and cardiac muscles | protein | 160 | 52% helix, 1% strand | P63317 |
| D | Troponin I, cardiac muscle | protein | 133 | 75% helix, 0% strand | A0A4X1V710 |
| E | Troponin T2, cardiac type | protein | 74 | 78% helix, 0% strand | A0A5G2Q8N0 |
| F, G | Tropomyosin alpha-1 chain | protein | 82 | 98% helix, 0% strand | P42639 |
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 893 | 0.81 | 0.84 | 94 | empty |
| 2 | 887 | 0.75 | 0.79 | 87 | empty |
| 3 | 415 | 0.69 | 0.81 | 45 | empty |
| 4 | 485 | 0.63 | 0.76 | 42 | empty |
| 5 | 238 | 0.60 | 0.80 | 33 | empty |
Interfaces
16 interfaces between chains.
- D–E · 2097 Ų buried · 18 hydrogen bonds · protein-protein
- F–G · 1901 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1181 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 998 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 740 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- P63317 · AlphaFold monomer V2.0 prediction for troponin C, slow skeletal and cardiac muscles… · a predicted model of the same protein · chain C against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B6VNT8
- Every structure of UniProt P63317
- Every structure of UniProt A0A4X1V710
- Every structure of UniProt A0A5G2Q8N0
- Every structure of UniProt P42639
- Elsewhere: RCSB PDB 8UWX · PDBe 8UWX · UniProt B6VNT8 · UniProt P63317 · UniProt A0A4X1V710 · UniProt A0A5G2Q8N0 · UniProt P42639
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