MolNFT v2 · #221173 · protein

The Crystal Structure of a human monoclonal antibody (aAb), termed TG10, complexed with a GlcNH2

8TN5 · TG10, Heavy chain: “The Crystal Structure of a human monoclonal antibody (aAb), termed TG10, complexed with a GlcNH2”. X-ray diffraction at 1.76, 3 ligands (GCS, SO4, CL), 3 pockets (best druggability 0.62). MolNFT v2 #221173 on…

PDB: 8TN5
Type: protein
Length: 436 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.76
Source: Homo sapiens
Molecule: TG10, Heavy chain; TG10, Light chain
Ligands: GCS, SO4, CL
Pockets: 3 · best druggability 0.62

Structure

x-ray diffraction · resolution 1.76 · 2 distinct chains · 10% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	TG10, Heavy chain	protein	221	13% helix, 49% strand	—
L	TG10, Light chain	protein	215	7% helix, 50% strand	—

Ligands and binding sites

GCS · 2-amino-2-deoxy-beta-D-glucopyranose · sugar · chains H, L
SO4 · Sulfate ion · ion · 8 copies · chains H, L
CL · Chloride ion · ion · chains H, L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	568	0.62	0.74	57	empty
2	115	0.49	0.80	26	empty
3	51	0.29	0.76	15	GCS

Interfaces

1 interface between chains.

H–L · 1985 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 8TN5 · PDBe 8TN5

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