MolNFT v2 · #219153 · protein
Cryo-EM structure of the transmembrane anti-sigma factor DdvA
8ROT · CHAT domain-containing protein: “Cryo-EM structure of the transmembrane anti-sigma factor DdvA”. Electron microscopy at 3.11, 20 pockets (best druggability 0.85). MolNFT v2 #219153 on GenesisL1: 3D structure, binding sites and…
- PDB
- 8ROT
- Type
- protein
- Length
- 1,794 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.11
- Source
- Myxococcus xanthus
- Molecule
- CHAT domain-containing protein
- UniProt
- Q1CW22
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · resolution 3.11 · 1 distinct chain · 56% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | CHAT domain-containing protein | protein | 897 | 56% helix, 8% strand | Q1CW22 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 837 | 0.85 | 0.88 | 91 | empty |
| 2 | 1079 | 0.84 | 0.85 | 85 | empty |
| 3 | 1066 | 0.77 | 0.79 | 91 | empty |
| 4 | 350 | 0.75 | 0.86 | 53 | empty |
| 5 | 551 | 0.65 | 0.76 | 57 | empty |
Interfaces
1 interface between chains.
- B–A · 1580 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q1CW22
- Elsewhere: RCSB PDB 8ROT · PDBe 8ROT · UniProt Q1CW22
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