MolNFT v2 · #218640 · protein

Crystal Structure of Cyclophilin TgCyp23 from Toxoplasma gondii in complex with NIM811 (N-methyl-4-isoleucine cyclosporin)

8R7S · Peptidyl-prolyl cis-trans isomerase: “Crystal Structure of Cyclophilin TgCyp23 from Toxoplasma gondii in complex with NIM811 (N-methyl-4-isoleucine…”. X-ray diffraction at 1.17. MolNFT v2 #218640 on GenesisL1: 3D structure, binding…

PDB: 8R7S
Type: protein
Length: 422 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.17
Source: Toxoplasma gondii; SYNTHETIC CONSTRUCT
Molecule: Peptidyl-prolyl cis-trans isomerase; CYCLOSPORIN A, 8 mutation
EC: 5.2.1.8
UniProt: A0A7J6KAD1

Structure

x-ray diffraction · resolution 1.17 · 2 distinct chains · 15% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)	protein	200	16% helix, 31% strand	A0A7J6KAD1
C, D	CYCLOSPORIN A, 8 mutation	protein	11	0% helix, 0% strand	—

Interfaces

3 interfaces between chains.

B–C · 528 Å² buried · 12 hydrogen bonds · protein-protein
A–D · 505 Å² buried · 11 hydrogen bonds · protein-protein
A–B · 464 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 modified, 2 d-amino (nonstandard, methylation, D-amino acid).

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A7J6KAD1
Elsewhere: RCSB PDB 8R7S · PDBe 8R7S · UniProt A0A7J6KAD1

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