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MolNFT v2 · #216570 · protein + RNA

11-mer ring of human metapneumovirus (HMPV) N-RNA

8PDM · Nucleoprotein: “11-mer ring of human metapneumovirus (HMPV) N-RNA”. Electron microscopy at 3.3, 5 pockets (best druggability 0.55). MolNFT v2 #216570 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
8PDM
Type
protein + RNA
Length
358 residues
Chains
2
Method
electron microscopy
Collection
MolNFT v2 / PDB Bank
Contract
0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner
0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution
3.3
Source
Escherichia coli; Human metapneumovirus (strain CAN97-83)
Molecule
Nucleoprotein; RNA
UniProt
Q6WBA1
Pockets
5 · best druggability 0.55

Structure

electron microscopy · resolution 3.3 · 2 distinct chains · 60% helix, 3% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ANucleoproteinprotein35160% helix, 3% strandQ6WBA1
BRNArna7——

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1510.550.9013empty
2930.500.8321empty
31880.440.7423empty
4500.400.8217empty
5610.300.7513empty

Interfaces

1 interface between chains.

  • A–B · 856 Ų buried · 27 hydrogen bonds · protein-nucleic

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