MolNFT v2 · #213275 · protein
Crystal structure of TRAF7 coiled-coil domain
8IMS · E3 ubiquitin-protein ligase TRAF7: “Crystal structure of TRAF7 coiled-coil domain”. X-ray diffraction at 3.3, 3 pockets (best druggability 0.50). MolNFT v2 #213275 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 8IMS
- Type
- protein
- Length
- 277 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.3
- Source
- Homo sapiens
- Molecule
- E3 ubiquitin-protein ligase TRAF7
- EC
- 2.3.2.27
- UniProt
- Q6Q0C0
- Pockets
- 3 · best druggability 0.50
Structure
x-ray diffraction · resolution 3.3 · 3 distinct chains · 93% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.27) | protein | 92 | 97% helix, 0% strand | Q6Q0C0 |
| A | E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.27) | protein | 93 | 90% helix, 0% strand | Q6Q0C0 |
| C | E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.27) | protein | 92 | 91% helix, 0% strand | Q6Q0C0 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 126 | 0.50 | 0.79 | 28 | empty |
| 2 | 96 | 0.42 | 0.77 | 17 | empty |
| 3 | 99 | 0.41 | 0.77 | 16 | empty |
Interfaces
3 interfaces between chains.
- B–A · 1849 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 1704 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 1689 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- Q6Q0C0 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase TRAF7 (Q6Q0C0) · a predicted model of the same protein · chain B against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6Q0C0
- Elsewhere: RCSB PDB 8IMS · PDBe 8IMS · UniProt Q6Q0C0
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