MolNFT v2 · #212182 · protein
Domain-stabilized glutamine-binding protein
8HNJ · Glutamine ABC transporter, periplasmic glutamine-binding…: “Domain-stabilized glutamine-binding protein”. X-ray diffraction at 2.03, 1 ligand (GLN), 7 pockets (best druggability 0.69). MolNFT v2 #212182 on GenesisL1: 3D structure…
- PDB
- 8HNJ
- Type
- protein
- Length
- 1,314 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.03
- Source
- Escherichia coli 908519
- Molecule
- Glutamine ABC transporter, periplasmic glutamine-binding protein GlnH
- UniProt
- V0VBD8
- Ligands
- GLN
- Pockets
- 7 · best druggability 0.69
Structure
x-ray diffraction · resolution 2.03 · 1 distinct chain · 39% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Glutamine ABC transporter, periplasmic glutamine-binding protein GlnH | protein | 219 | 39% helix, 31% strand | V0VBD8 |
Ligands and binding sites
- GLN · Glutamine · ligand · 6 copies · chains A, B, C, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 692 | 0.69 | 0.77 | 85 | empty |
| 2 | 139 | 0.66 | 0.87 | 41 | GLN |
| 3 | 55 | 0.48 | 0.86 | 22 | GLN |
| 4 | 70 | 0.47 | 0.83 | 25 | GLN |
| 5 | 53 | 0.47 | 0.85 | 21 | GLN |
Interfaces
7 interfaces between chains.
- B–C · 288 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 232 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 203 Ų buried · 0 hydrogen bonds · protein-protein
- B–E · 91 Ų buried · 1 hydrogen bond · protein-protein
- A–F · 87 Ų buried · 0 hydrogen bonds · protein-protein
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt V0VBD8
- Elsewhere: RCSB PDB 8HNJ · PDBe 8HNJ · UniProt V0VBD8
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