MolNFT v2 · #211311 · protein
Crystal structure of anti-FIXa IgG fab with FAST-Ig mutations
8GUZ · Anti-factor IXa IgG fab heavy chain: “Crystal structure of anti-FIXa IgG fab with FAST-Ig mutations”. X-ray diffraction at 1.79, 10 pockets (best druggability 0.64). MolNFT v2 #211311 on GenesisL1: 3D structure, binding sites and…
- PDB
- 8GUZ
- Type
- protein
- Length
- 867 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.79
- Source
- Homo sapiens
- Molecule
- Anti-factor IXa IgG fab heavy chain; Anti-factor IXa IgG fab light chain
- Pockets
- 10 · best druggability 0.64
Structure
x-ray diffraction · resolution 1.79 · 3 distinct chains · 8% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Anti-factor IXa IgG fab heavy chain | protein | 219 | 8% helix, 50% strand | — |
| B, D | Anti-factor IXa IgG fab light chain | protein | 214 | 7% helix, 50% strand | — |
| C | Anti-factor IXa IgG fab heavy chain | protein | 220 | 9% helix, 51% strand | — |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 28 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 612 | 0.64 | 0.75 | 64 | EDO |
| 2 | 596 | 0.63 | 0.75 | 64 | empty |
| 3 | 363 | 0.62 | 0.78 | 48 | EDO |
| 4 | 133 | 0.58 | 0.84 | 24 | empty |
| 5 | 96 | 0.45 | 0.79 | 17 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1816 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1744 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 214 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 70 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 8GUZ · PDBe 8GUZ
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.