MolNFT v2 · #209358 · protein
BRAF kinase in complex with LXH254 (naporafenib)
8F7P: “BRAF kinase in complex with LXH254 (naporafenib)”. X-ray diffraction at 2.74, 1 ligand (K81). MolNFT v2 #209358 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 8F7P
- Type
- protein
- Length
- 520 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.74
- Source
- Homo sapiens
- UniProt
- P15056
- Ligands
- K81
Structure
x-ray diffraction · resolution 2.74 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 255 | — | P15056 |
| B | — | protein | 265 | — | P15056 |
Ligands and binding sites
- K81 · N-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- P15056 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase B-RAF (P15056) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15056
- Elsewhere: RCSB PDB 8F7P · PDBe 8F7P · UniProt P15056
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