MolNFT v2 · #204578 · protein
Crystal structure of PPARG and NCOR2 with an inverse agonist (compound 15b)
8B93: “Crystal structure of PPARG and NCOR2 with an inverse agonist (compound 15b)”. X-ray diffraction at 2.21, 1 ligand (Q8F). MolNFT v2 #204578 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 8B93
- Type
- protein
- Length
- 513 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.21
- Source
- Homo sapiens; SYNTHETIC CONSTRUCT
- UniProt
- P37231, Q9Y618
- Ligands
- Q8F
Structure
x-ray diffraction · resolution 2.21 · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 248 | — | P37231 |
| B | — | protein | 241 | — | P37231 |
| C | — | protein | 12 | — | Q9Y618 |
| D | — | protein | 12 | — | Q9Y618 |
Ligands and binding sites
- Q8F · 4-chloranyl-6-fluoranyl-~{N}1-[[4-fluoranyl-2-(2-methoxyethoxymethyl)phenyl]methyl]-~{N}3-[2-methyl-4-(trifluoromethyl)phenyl]benzene-1,3-dicarboxamide · ligand · 2 copies · chains A, C, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- Q9Y618 · AlphaFold monomer V2.0 prediction for nuclear receptor corepressor 2 (Q9Y618) · a predicted model of the same protein · chain C against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37231
- Every structure of UniProt Q9Y618
- Elsewhere: RCSB PDB 8B93 · PDBe 8B93 · UniProt P37231 · UniProt Q9Y618
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