MolNFT v2 · #197071 · protein + RNA

Crystal structure of APOBEC3G complex with ssRNA

7UU4 · DNA dC->dU-editing enzyme APOBEC-3G: “Crystal structure of APOBEC3G complex with ssRNA”. X-ray diffraction at 2.1, 2 ligands (ZN, SO4), 4 pockets (best druggability 0.51). MolNFT v2 #197071 on GenesisL1: 3D structure, binding sites…

PDB: 7UU4
Type: protein + RNA
Length: 379 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.1
Source: Macaca mulatta; SYNTHETIC CONSTRUCT
Molecule: DNA dC->dU-editing enzyme APOBEC-3G; RNA (5'-R(P*UP*AP*AP*UP*UP*U)-3')
EC: 3.5.4.-
UniProt: M1GSK9
Ligands: ZN, SO4
Pockets: 4 · best druggability 0.51

Structure

x-ray diffraction · resolution 2.1 · 2 distinct chains · 40% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA dC->dU-editing enzyme APOBEC-3G (EC 3.5.4.-)	protein	373	40% helix, 23% strand	M1GSK9
R	RNA (5'-R(PUPAPAPUPUPU)-3')	rna	6	—	—

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	139	0.51	0.80	20	empty
2	153	0.51	0.79	29	empty
3	82	0.35	0.75	14	empty
4	66	0.32	0.75	15	empty

Interfaces

1 interface between chains.

A–R · 851 Å² buried · 26 hydrogen bonds · protein-nucleic

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt M1GSK9
Elsewhere: RCSB PDB 7UU4 · PDBe 7UU4 · UniProt M1GSK9

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