MolNFT v2 · #194999 · protein
Structure of SARS-CoV-2 3CL protease in complex with inhibitor 10c
7T49: “Structure of SARS-CoV-2 3CL protease in complex with inhibitor 10c”. X-ray diffraction at 1.75, 2 ligands (FV5, FVE). MolNFT v2 #194999 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7T49
- Type
- protein
- Length
- 598 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.75
- Source
- Severe acute respiratory syndrome coronavirus 2
- UniProt
- P0DTD1
- Ligands
- FV5, FVE
Structure
x-ray diffraction · resolution 1.75 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 298 | — | P0DTD1 |
| B | — | protein | 300 | — | P0DTD1 |
Ligands and binding sites
- FV5 · (1R,2S)-1-hydroxy-2-{[N-({[7-(methanesulfonyl)-7-azaspiro[3.5]nonan-2-yl]oxy}carbonyl)-L-leucyl]amino}-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid · ligand · 2 copies · chains A, B
- FVE · (1S,2S)-1-hydroxy-2-{[N-({[7-(methanesulfonyl)-7-azaspiro[3.5]nonan-2-yl]oxy}carbonyl)-L-leucyl]amino}-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7T49 · Structure of SARS-cov-2 3CL protease in complex with inhibitor 10C · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DTD1
- Elsewhere: RCSB PDB 7T49 · PDBe 7T49 · UniProt P0DTD1
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