MolNFT v2 · #188363 · protein
Structure of the mature RSV CA lattice: Group III, hexamer-hexamer interface, class 3'5
7NOE · Capsid protein p27, alternate cleaved 1: “Structure of the mature RSV CA lattice: Group III, hexamer-hexamer interface, class 3'5”. Electron microscopy at 7.5, 14 pockets (best druggability 0.58). MolNFT v2 #188363 on GenesisL1: 3D…
- PDB
- 7NOE
- Type
- protein
- Length
- 1,302 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 7.5
- Source
- Rous sarcoma virus (strain Prague C)
- Molecule
- Capsid protein p27, alternate cleaved 1
- UniProt
- P03322
- Pockets
- 14 · best druggability 0.58
Structure
electron microscopy · resolution 7.5 · 3 distinct chains · 66% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, G, I | Capsid protein p27, alternate cleaved 1 | protein | 78 | 63% helix, 0% strand | P03322 |
| B, E | Capsid protein p27, alternate cleaved 1 | protein | 217 | 66% helix, 0% strand | P03322 |
| C, F, H, J | Capsid protein p27, alternate cleaved 1 | protein | 139 | 68% helix, 0% strand | P03322 |
Pockets
14 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 611 | 0.58 | 0.73 | 101 | empty |
| 2 | 463 | 0.54 | 0.73 | 87 | empty |
| 3 | 383 | 0.51 | 0.73 | 76 | empty |
| 4 | 254 | 0.46 | 0.73 | 57 | empty |
| 5 | 273 | 0.46 | 0.73 | 43 | empty |
Interfaces
12 interfaces between chains.
- B–C · 181 Ų buried · 0 hydrogen bonds · protein-protein
- E–F · 165 Ų buried · 0 hydrogen bonds · protein-protein
- D–G · 98 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 84 Ų buried · 0 hydrogen bonds · protein-protein
- D–E · 83 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7NOE · Structure of the mature rsv ca lattice: group III, hexamer-hexamer interface, class 3'5 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03322
- Elsewhere: RCSB PDB 7NOE · PDBe 7NOE · UniProt P03322
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