GL1X · GenesisL1 explorer

MolNFT v2 · #187321 · protein + RNA

Mtb 70SIC in complex with MtbEttA at Pre_R1 state

7MSH: “Mtb 70SIC in complex with MtbEttA at Pre_R1 state”. Electron microscopy at 3.23, 3 ligands (ANP, MG, ZN). MolNFT v2 #187321 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
7MSH
Type
protein + RNA
Length
10,982 residues
Chains
55
Method
electron microscopy
Collection
MolNFT v2 / PDB Bank
Contract
0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner
0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution
3.23
Source
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); Mycobacterium…
UniProt
P9WH99, P9WH95, P9WH93, P9WH91, P9WH89, P9WHA1, A0A3E0UTA6, P9WHC7, P9WHA5, P9WH87, P9WH85, P9WH83, P9WH81, P9WH79, A0A0T9D5H2, A0A045HTP7, P9WHD7, P9WHD5, P9WHD3, P9WHD1, P9WHC9, P9WHC5, P9WHC3, P9WHC1, P9WHB9, P9WHB7, P9WHB5, P9WHB3, A0A045IDB8, P9WHA7, P9WHA3, P9WH37, P9WH35, P9WH33, P9WH31, P9WH29, P9WH27, P9WH25, P9WH67, P9WH65, P9WH63, P9WH61, P9WH57, P9WH55, P9WH53, P9WH51, P9WH49, P9WH45, P9WH41, P9WQK3
Ligands
ANP, MG, ZN

Structure

electron microscopy · resolution 3.23 · 55 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
0—protein54—P9WH99
1—protein48—P9WH95
2—protein44—P9WH93
3—protein62—P9WH91
4—protein37—P9WH89
6—protein47—P9WHA1
7—protein8—A0A3E0UTA6
8—protein230—P9WHC7
A—rna3118——
B—rna115——
C—protein272—P9WHA5
D—protein213—P9WH87
E—protein207—P9WH85
F—protein178—P9WH83
G—protein174—P9WH81
H—protein47—P9WH79
J—protein146—A0A0T9D5H2
K—protein122—A0A045HTP7
L—protein144—P9WHD7
M—protein134—P9WHD5
N—protein116—P9WHD3
O—protein119—P9WHD1
P—protein112—P9WHC9
Q—protein124—P9WHC5
R—protein100—P9WHC3
S—protein113—P9WHC1
T—protein95—P9WHB9
U—protein90—P9WHB7
V—protein177—P9WHB5
W—protein72—P9WHB3
X—protein62—A0A045IDB8
Y—protein68—P9WHA7
Z—protein59—P9WHA3
a—rna1519——
c—protein207—P9WH37
d—protein200—P9WH35
e—protein169—P9WH33
f—protein95—P9WH31
g—protein155—P9WH29
h—protein131—P9WH27
i—protein127—P9WH25
j—protein99—P9WH67
k—protein117—P9WH65
l—protein122—P9WH63
m—protein116—P9WH61
n—protein60—P9WH57
o—protein87—P9WH55
p—protein113—P9WH53
q—protein95—P9WH51
r—protein64—P9WH49
s—protein83—P9WH45
t—protein85—P9WH41
x—protein550—P9WQK3
y—rna75——
z—rna6——

Ligands and binding sites

  • ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 2 copies · chains x
  • MG · Magnesium ion · metal · 420 copies · chains A, C, 0, E, T, 2, J, M, Q, B, D, H, L, a, e, d, x, r, t, y
  • ZN · Zinc ion · metal · 6 copies · chains 1, 4, 6, X, n, r

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • P9WHA5 · AlphaFold monomer V2.0 prediction for 50S ribosomal protein L2 (P9WHA5) · a predicted model of the same protein · chain C against A, TM-score 0.99
  • P9WHD3 · AlphaFold monomer V2.0 prediction for 50S ribosomal protein L17 (P9WHD3) · a predicted model of the same protein · chain N against A, TM-score 0.99
  • P9WHC5 · AlphaFold monomer V2.0 prediction for 50S ribosomal protein L20 (P9WHC5) · a predicted model of the same protein · chain Q against A, TM-score 0.99
  • P9WHC1 · AlphaFold monomer V2.0 prediction for 50S ribosomal protein L22 (P9WHC1) · a predicted model of the same protein · chain S against A, TM-score 0.99
  • P9WH27 · AlphaFold monomer V2.0 prediction for 30S ribosomal protein S8 (P9WH27) · a predicted model of the same protein · chain h against A, TM-score 0.99
  • P9WH33 · AlphaFold monomer V2.0 prediction for 30S ribosomal protein S5 (P9WH33) · a predicted model of the same protein · chain e against A, TM-score 0.98
  • P9WHD5 · AlphaFold monomer V2.0 prediction for 50S ribosomal protein L16 (P9WHD5) · a predicted model of the same protein · chain M against A, TM-score 0.98
  • P9WH85 · AlphaFold monomer V2.0 prediction for 50S ribosomal protein L4 (P9WH85) · a predicted model of the same protein · chain E against A, TM-score 0.98
  • P9WHD1 · AlphaFold monomer V2.0 prediction for 50S ribosomal protein L18 (P9WHD1) · a predicted model of the same protein · chain O against A, TM-score 0.98
  • P9WH87 · AlphaFold monomer V2.0 prediction for 50S ribosomal protein L3 (P9WH87) · a predicted model of the same protein · chain D against A, TM-score 0.98
  • P9WH37 · AlphaFold monomer V2.0 prediction for 30S ribosomal protein S3 (P9WH37) · a predicted model of the same protein · chain c against A, TM-score 0.98
  • P9WH35 · AlphaFold monomer V2.0 prediction for 30S ribosomal protein S4 (P9WH35) · a predicted model of the same protein · chain d against A, TM-score 0.98

Analyse

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