MolNFT v2 · #187077 · protein
Crystal structure of human PI3Ka (p110a subunit) with MMV085400 bound to the active site determined at 2.9 angstroms resolution
7MLK: “Crystal structure of human PI3Ka (p110a subunit) with MMV085400 bound to the active site determined at 2.9…”. X-ray diffraction at 2.91, 1 ligand (ZHY). MolNFT v2 #187077 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7MLK
- Type
- protein
- Length
- 888 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.91
- Source
- Homo sapiens
- UniProt
- P42336
- Ligands
- ZHY
Structure
x-ray diffraction · resolution 2.91 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 888 | — | P42336 |
Ligands and binding sites
- ZHY · 4-[6-(3,4,5-trimethoxyanilino)pyrazin-2-yl]benzamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7MLK · Crystal structure of human PI3KA (P110A subunit) with MMV085400 bound to the active site… · the same entry in another collection · chain A against A, TM-score 1.00
- P42336 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42336
- Elsewhere: RCSB PDB 7MLK · PDBe 7MLK · UniProt P42336
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