MolNFT v2 · #185863 · protein
High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-150.
7LL5: “High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-150.”. X-ray diffraction at 1.5, 1 ligand (Y5G). MolNFT v2 #185863 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7LL5
- Type
- protein
- Length
- 291 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.5
- Source
- Homo sapiens
- UniProt
- O60674
- Ligands
- Y5G
Structure
x-ray diffraction · resolution 1.5 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 291 | — | O60674 |
Ligands and binding sites
- Y5G · {1-(ethylsulfonyl)-3-[4-(2-{[4-(1-methylpiperidin-4-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile · ligand · chains A
- EDO · 1,2-ethanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7LL5 · High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-150. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60674
- Elsewhere: RCSB PDB 7LL5 · PDBe 7LL5 · UniProt O60674
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