MolNFT v2 · #184637 · protein
Structure of the catalytic domain of tankyrase 1 in complex with talazoparib
7KKN: “Structure of the catalytic domain of tankyrase 1 in complex with talazoparib”. X-ray diffraction at 1.48, 2 ligands (2YQ, ZN). MolNFT v2 #184637 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7KKN
- Type
- protein
- Length
- 834 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.48
- Source
- Homo sapiens
- UniProt
- Q59FX0
- Ligands
- 2YQ, ZN
Structure
x-ray diffraction · resolution 1.48 · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 207 | — | Q59FX0 |
| B, D | — | protein | 210 | — | Q59FX0 |
| C | — | protein | 207 | — | Q59FX0 |
Ligands and binding sites
- 2YQ · (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2, 4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one · ligand · 4 copies · chains A, B, C, D
- ZN · Zinc ion · metal · 4 copies · chains A, B, C, D
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7KKN · Structure of the catalytic domain of tankyrase 1 in complex with talazoparib · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q59FX0
- Elsewhere: RCSB PDB 7KKN · PDBe 7KKN · UniProt Q59FX0
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