MolNFT v2 · #175112 · protein
MlghB, GDP-mannoheptose C3,5 epimerase from Campylobacter jejuni
7ANG · Thymidine diphospho-4-keto-rhamnose 3,5-epimerase: “MlghB, GDP-mannoheptose C3,5 epimerase from Campylobacter jejuni”. X-ray diffraction at 2.14, 7 pockets (best druggability 0.67). MolNFT v2 #175112 on GenesisL1: 3D structure…
- PDB
- 7ANG
- Type
- protein
- Length
- 678 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.14
- Source
- Campylobacter jejuni
- Molecule
- Thymidine diphospho-4-keto-rhamnose 3,5-epimerase
- EC
- 5.1.3.13
- UniProt
- A0A2U0QM91
- Pockets
- 7 · best druggability 0.67
Structure
x-ray diffraction · resolution 2.14 · 4 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thymidine diphospho-4-keto-rhamnose 3,5-epimerase (EC 5.1.3.13) | protein | 177 | 8% helix, 48% strand | A0A2U0QM91 |
| B | Thymidine diphospho-4-keto-rhamnose 3,5-epimerase (EC 5.1.3.13) | protein | 167 | 7% helix, 50% strand | A0A2U0QM91 |
| C | Thymidine diphospho-4-keto-rhamnose 3,5-epimerase (EC 5.1.3.13) | protein | 163 | 4% helix, 53% strand | A0A2U0QM91 |
| D | Thymidine diphospho-4-keto-rhamnose 3,5-epimerase (EC 5.1.3.13) | protein | 171 | 7% helix, 50% strand | A0A2U0QM91 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 748 | 0.67 | 0.75 | 71 | empty |
| 2 | 194 | 0.58 | 0.81 | 30 | empty |
| 3 | 225 | 0.55 | 0.78 | 31 | empty |
| 4 | 175 | 0.51 | 0.78 | 29 | empty |
| 5 | 50 | 0.38 | 0.81 | 18 | empty |
Interfaces
5 interfaces between chains.
- A–D · 1673 Ų buried · 40 hydrogen bonds · protein-protein
- B–C · 1639 Ų buried · 36 hydrogen bonds · protein-protein
- A–C · 312 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 309 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 104 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7ANG · Mlghb, GDP-mannoheptose C3,5 epimerase from campylobacter jejuni · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2U0QM91
- Elsewhere: RCSB PDB 7ANG · PDBe 7ANG · UniProt A0A2U0QM91
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