MolNFT v2 · #172867 · protein

Human Brd2(BD2) L383V mutant in complex with ET-JQ1-OMe

6YTM: “Human Brd2(BD2) L383V mutant in complex with ET-JQ1-OMe”. X-ray diffraction at 1.56, 2 ligands (PMW, PXN). MolNFT v2 #172867 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6YTM
Type: protein
Length: 218 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.56
Source: Homo sapiens
UniProt: P25440
Ligands: PMW, PXN

Structure

x-ray diffraction · resolution 1.56 · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	110	—	P25440
B	—	protein	108	—	P25440

Ligands and binding sites

PMW · Methyl (R)-2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)butanoate · ligand · 2 copies · chains A, B
PXN · (2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6YTM · Human BRD2(BD2) L383V mutant in complex with et-JQ1-ome · the same entry in another collection · chain A against A, TM-score 1.00
P25440 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 2 (P25440) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25440
Elsewhere: RCSB PDB 6YTM · PDBe 6YTM · UniProt P25440

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