MolNFT v2 · #162318 · protein
OXA-48_P68A-CAZ. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance
6Q5F: “OXA-48_P68A-CAZ. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance”. X-ray diffraction at 2.5, 3 ligands (CTJ, CL, SO4). MolNFT v2 #162318 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6Q5F
- Type
- protein
- Length
- 942 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.5
- Source
- Klebsiella pneumoniae
- UniProt
- Q6XEC0
- Ligands
- CTJ, CL, SO4
Structure
x-ray diffraction · resolution 2.5 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | — | protein | 229 | — | Q6XEC0 |
| B, D | — | protein | 242 | — | Q6XEC0 |
Ligands and binding sites
- CTJ · 1-({(2R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium · ligand · 2 copies · chains A, C
- CL · Chloride ion · ion · 6 copies · chains A, B, C, D
- SO4 · Sulfate ion · ion · chains D
- PGE · Triethylene glycol · additive · 3 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6Q5F · Oxa-48_P68A-caz. evolutionary trade-offs of oxa-48 mediated ceftazidime-avibactam… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6XEC0
- Elsewhere: RCSB PDB 6Q5F · PDBe 6Q5F · UniProt Q6XEC0
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