MolNFT v2 · #15992 · protein

crystal structure of anti-HCV monoclonal antibody 19D9D6

1NLB · antibody 19D9D6 light chain: “crystal structure of anti-HCV monoclonal antibody 19D9D6”. X-ray diffraction at 1.6, 4 pockets (best druggability 0.55). MolNFT v2 #15992 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1NLB
Type: protein
Length: 438 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.6
Source: Mus musculus
Molecule: antibody 19D9D6 light chain; antibody 19D9D6 heavy chain
Pockets: 4 · best druggability 0.55

Structure

x-ray diffraction · resolution 1.6 · 2 distinct chains · 8% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	antibody 19D9D6 light chain	protein	220	8% helix, 52% strand	—
H	antibody 19D9D6 heavy chain	protein	218	8% helix, 53% strand	—

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	352	0.55	0.74	59	empty
2	124	0.51	0.80	20	empty
3	84	0.31	0.73	22	empty
4	61	0.28	0.74	18	empty

Interfaces

1 interface between chains.

L–H · 1871 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1NLB · Crystal structure of anti-HCV monoclonal antibody 19D9D6 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1NLB · PDBe 1NLB

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