MolNFT v2 · #159634 · protein

Structure of human pregnane X receptor ligand binding domain bound tethered with src co-activator peptide and compound-3 aka 1,1,1,3,3,3-hexafluoro-2-{4-[1-(4- LUOROBENZENESULFONYL)CYCLOPENTYL]PHENYL}PROPAN-2-ol

6NX1: “Structure of human pregnane X receptor ligand binding domain bound tethered with src co-activator peptide and…”. X-ray diffraction at 2.27, 1 ligand (L7D). MolNFT v2 #159634 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6NX1
Type: protein
Length: 582 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.27
Source: Homo sapiens
UniProt: O75469, Q15788
Ligands: L7D

Structure

x-ray diffraction · resolution 2.27 · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	288	—	O75469, Q15788
B	—	protein	294	—	O75469, Q15788

Ligands and binding sites

L7D · 1,1,1,3,3,3-hexafluoro-2-(4-{1-[(4-fluorophenyl) sulfonyl]cyclopentyl}phenyl)propan-2-ol · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6NX1 · Structure of human pregnane X receptor ligand binding domain bound tethered with src… · the same entry in another collection · chain A against A, TM-score 1.00
O75469 · AlphaFold monomer V2.0 prediction for nuclear receptor subfamily 1 group I member 2… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75469
Every structure of UniProt Q15788
Elsewhere: RCSB PDB 6NX1 · PDBe 6NX1 · UniProt O75469 · UniProt Q15788

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