MolNFT v2 · #159522 · protein

Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-232

6NTK: “Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-232”. X-ray diffraction at 2.406, 3 ligands (L0S, NAG, FUC). MolNFT v2 #159522 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6NTK
Type: protein
Length: 1,058 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.406
Source: Homo sapiens
UniProt: P22303
Ligands: L0S, NAG, FUC

Structure

x-ray diffraction · resolution 2.406 · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	531	—	P22303
B	—	protein	527	—	P22303

Ligands and binding sites

L0S · methyl (R)-N-[(1E)-1-(diethylamino)ethylidene]-P-methylphosphonamidate · ligand · 2 copies · chains A, B
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 5 copies · chains A, B
FUC · alpha-L-fucopyranose · sugar · 2 copies · chains B
7PE · 2-(2-(2-(2-(2-(2-ethoxyethoxy)ethoxy)ethoxy)ethoxy) ethoxy)ethanol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6NTK · Crystal structure of recombinant human acetylcholinesterase inhibited by a-232 · the same entry in another collection · chain A against A, TM-score 1.00
P22303 · AlphaFold monomer V2.0 prediction for acetylcholinesterase (P22303) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22303
Elsewhere: RCSB PDB 6NTK · PDBe 6NTK · UniProt P22303

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.