MolNFT v2 · #159034 · protein
CYCLIC GMP-AMP SYNTHASE in complex with compound 16 inhibitor: 7-hydroxy-N-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
6NFG: “CYCLIC GMP-AMP SYNTHASE in complex with compound 16 inhibitor…”. X-ray diffraction at 2.76, 2 ligands (KKP, ZN). MolNFT v2 #159034 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6NFG
- Type
- protein
- Length
- 694 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.76
- Source
- Homo sapiens
- UniProt
- Q8N884
- Ligands
- KKP, ZN
Structure
x-ray diffraction · resolution 2.76 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 348 | — | Q8N884 |
| B | — | protein | 346 | — | Q8N884 |
Ligands and binding sites
- KKP · 7-hydroxy-N-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide · ligand · 2 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6NFG · Cyclic gmp-AMP synthase in complex with compound 16 inhibitor: 7… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8N884 · AlphaFold monomer V2.0 prediction for cyclic gmp-AMP synthase (Q8N884) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N884
- Elsewhere: RCSB PDB 6NFG · PDBe 6NFG · UniProt Q8N884
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