MolNFT v2 · #158766 · protein
Structure of the human JAK1 kinase domain with compound 56
6N7C: “Structure of the human JAK1 kinase domain with compound 56”. X-ray diffraction at 1.69, 1 ligand (KF1). MolNFT v2 #158766 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6N7C
- Type
- protein
- Length
- 548 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.69
- Source
- Homo sapiens
- UniProt
- P23458
- Ligands
- KF1
Structure
x-ray diffraction · resolution 1.69 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 275 | — | P23458 |
| B | — | protein | 273 | — | P23458 |
Ligands and binding sites
- KF1 · N-[5-(3-methoxynaphthalen-2-yl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide · ligand · 2 copies · chains A, B
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6N7C · Structure of the human JAK1 kinase domain with compound 56 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23458
- Elsewhere: RCSB PDB 6N7C · PDBe 6N7C · UniProt P23458
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