MolNFT v2 · #158762 · protein

Structure of the human JAK1 kinase domain with compound 21

6N78: “Structure of the human JAK1 kinase domain with compound 21”. X-ray diffraction at 1.83, 1 ligand (KEP). MolNFT v2 #158762 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6N78
Type: protein
Length: 277 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.83
Source: Homo sapiens
UniProt: P23458
Ligands: KEP

Structure

x-ray diffraction · resolution 1.83 · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	277	—	P23458

Ligands and binding sites

KEP · N-{3-[5-chloro-2-(difluoromethoxy)phenyl]-1-methyl-1H-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide · ligand · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6N78 · Structure of the human JAK1 kinase domain with compound 21 · the same entry in another collection · chain A against A, TM-score 1.00
P23458 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase JAK1 (P23458) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23458
Elsewhere: RCSB PDB 6N78 · PDBe 6N78 · UniProt P23458

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