Human ERAP1 bound to phosphinic pseudotripeptide inhibitor DG013

Structure

x-ray diffraction · resolution 3.31 · 1 distinct chain.

Ligands and binding sites

• P52 · Nalpha-[(2S)-2-{[[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]methyl}-4-methylpentanoyl]-L-tryptophanamide · ligand · 22 copies · chains A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 110 copies · chains A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V
• BMA · beta-D-mannopyranose · sugar · 44 copies
• ZN · Zinc ion · metal · 22 copies · chains A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V
• SO4 · Sulfate ion · ion · 309 copies · chains A, D, B, H, F, C, J, E, L, G, K, I, N, Q, M, P, U, O, S, T, R, V

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• Q9NZ08 · AlphaFold monomer V2.0 prediction for endoplasmic reticulum aminopeptidase 1 (Q9NZ08) · a predicted model of the same protein · chain G against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9NZ08
• Elsewhere: RCSB PDB 6M8P · PDBe 6M8P · UniProt Q9NZ08