MolNFT v2 · #157386 · protein
Crystal structure of PA4853 (Fis) from Pseudomonas aeruginosa
6M10 · Putative Fis-like DNA-binding protein: “Crystal structure of PA4853 (Fis) from Pseudomonas aeruginosa”. X-ray diffraction at 2.985, 4 pockets (best druggability 0.42). MolNFT v2 #157386 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6M10
- Type
- protein
- Length
- 324 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.985
- Source
- Pseudomonas aeruginosa PAO1
- Molecule
- Putative Fis-like DNA-binding protein
- UniProt
- Q9HUW0
- Pockets
- 4 · best druggability 0.42
Structure
x-ray diffraction · resolution 2.985 · 3 distinct chains · 62% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative Fis-like DNA-binding protein | protein | 83 | 58% helix, 0% strand | Q9HUW0 |
| C, B | Putative Fis-like DNA-binding protein | protein | 80 | 65% helix, 0% strand | Q9HUW0 |
| D | Putative Fis-like DNA-binding protein | protein | 81 | 63% helix, 0% strand | Q9HUW0 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 98 | 0.42 | 0.78 | 17 | empty |
| 2 | 58 | 0.34 | 0.77 | 10 | empty |
| 3 | 54 | 0.33 | 0.78 | 16 | empty |
| 4 | 55 | 0.29 | 0.75 | 9 | empty |
Interfaces
4 interfaces between chains.
- A–B · 1671 Ų buried · 13 hydrogen bonds · protein-protein
- B–D · 321 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 300 Ų buried · 6 hydrogen bonds · protein-protein
- C–B · 82 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6M10 · Crystal structure of PA4853 (fis) from pseudomonas aeruginosa · the same entry in another collection · chain D against D, TM-score 1.00
- Q9HUW0 · AlphaFold monomer V2.0 prediction for putative fis-like DNA-binding protein (Q9HUW0) · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HUW0
- Elsewhere: RCSB PDB 6M10 · PDBe 6M10 · UniProt Q9HUW0
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