MolNFT v2 · #156886 · protein

Two-component system protein mediate signal transduction

6LKL · ABC transporter, solute-binding protein: “Two-component system protein mediate signal transduction”. X-ray diffraction at 2.213, 4 pockets (best druggability 0.76). MolNFT v2 #156886 on GenesisL1: 3D structure, binding sites and…

PDB: 6LKL
Type: protein
Length: 588 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.213
Source: Staphylococcus aureus
Molecule: ABC transporter, solute-binding protein
UniProt: X5DVD1
Pockets: 4 · best druggability 0.76

Structure

x-ray diffraction · resolution 2.213 · 1 distinct chain · 41% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	ABC transporter, solute-binding protein	protein	294	41% helix, 20% strand	X5DVD1

Ligands and binding sites

MLA · Malonic acid · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	882	0.76	0.80	83	MLA
2	328	0.72	0.84	37	MLA
3	203	0.56	0.80	31	empty
4	202	0.56	0.79	32	empty

Interfaces

1 interface between chains.

A–B · 557 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

6LKL · Two-component system protein mediate signal transduction · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt X5DVD1
Elsewhere: RCSB PDB 6LKL · PDBe 6LKL · UniProt X5DVD1

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