MolNFT v2 · #156744 · protein
crystal structure of the first bromodomain of human BRD4 in complex with compound BDF-2138
6LG8: “crystal structure of the first bromodomain of human BRD4 in complex with compound BDF-2138”. X-ray diffraction at 1.58, 1 ligand (ECR). MolNFT v2 #156744 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6LG8
- Type
- protein
- Length
- 124 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.58
- Source
- Homo sapiens
- UniProt
- O60885
- Ligands
- ECR
Structure
x-ray diffraction · resolution 1.58 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 124 | — | O60885 |
Ligands and binding sites
- ECR · 2-azanyl-5-fluoranyl-4-imidazol-1-yl-quinolin-8-ol · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6LG8 · Crystal structure of the first bromodomain of human BRD4 in complex with compound bdf-2138 · the same entry in another collection · chain A against A, TM-score 1.00
- O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60885
- Elsewhere: RCSB PDB 6LG8 · PDBe 6LG8 · UniProt O60885
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