MolNFT v2 · #15626 · DNA
The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes
1NAB · 5'-D(*CP*GP*AP*TP*CP*G)-3': “The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG)…”. X-ray diffraction at 2.15, 1 ligand (44D). MolNFT v2 #15626 on GenesisL1: 3D structure, binding…
- PDB
- 1NAB
- Type
- DNA
- Length
- 12 nucleotides
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.15
- Molecule
- 5'-D(*CP*GP*AP*TP*CP*G)-3'
- Ligands
- 44D
Structure
x-ray diffraction · resolution 2.15 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 5'-D(*CP*GP*AP*TP*CP*G)-3' | dna | 6 | — | — |
Ligands and binding sites
- 44D · 7-[5-(4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy]-6,9,11-trihydroxy-9-(2-hydroxy-acetyl)-7,8,9,10-tetrahydro-naphthacene-5,12-dione · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 274 Ų buried · 18 hydrogen bonds · nucleic-nucleic
Compared structures
- 1NAB · The crystal structure of the complex between a disaccharide anthracycline and the DNA… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1NAB · PDBe 1NAB
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