MolNFT v2 · #155343 · protein
Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Hendra virus-derived peptide HeV1--human beta-2 microglobulin
6K7T · MHC class I antigen: “Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Hendra virus-derived…”. X-ray diffraction at 1.6, 5 pockets (best druggability 0.69). MolNFT v2 #155343 on GenesisL1: 3D…
- PDB
- 6K7T
- Type
- protein
- Length
- 360 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.6
- Source
- Homo sapiens; Pteropus alecto; SYNTHETIC CONSTRUCT
- Molecule
- MHC class I antigen; Beta-2-microglobulin; HeV1
- UniProt
- A0A125R585, P61769
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · resolution 1.6 · 3 distinct chains · 21% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MHC class I antigen | protein | 253 | 29% helix, 36% strand | A0A125R585 |
| B | Beta-2-microglobulin | protein | 99 | 0% helix, 49% strand | P61769 |
| C | HeV1 | protein | 8 | 0% helix, 0% strand | — |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 441 | 0.69 | 0.81 | 47 | empty |
| 2 | 79 | 0.38 | 0.78 | 25 | empty |
| 3 | 63 | 0.36 | 0.78 | 15 | empty |
| 4 | 73 | 0.33 | 0.75 | 16 | empty |
| 5 | 56 | 0.24 | 0.72 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1389 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 901 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6K7T · Crystal structure of bat (pteropus alecto) MHC class I ptal-N*01:01 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A125R585
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 6K7T · PDBe 6K7T · UniProt A0A125R585 · UniProt P61769
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